Poster 5-Ji-Sun Moon
Kyungpook Nartional University, Korea
Title: A Furan Fatty Acid 7,10-epoxy octadeca 7,9-dienoic acid : A synergistic antibacterial agent against multidrug-resistant Staphylococcus aureus
Biography
Biography: Poster 5-Ji-Sun Moon
Abstract
Structural modifi cation of natural lipids by biocatalysis can change their properties or even create novel functionalities.
Hydroxy fatty acid, one of oxylipins, can be produced from the microbial bioconversion of natural vegetable oils. Recently
7,10-dihydroxy-8(E)-octadecenoic acid (DOD) was produced with high yield from olive oil containing oleic acid by bacterial strain Pseudomonas aeruginosa PR3, and further study confi rmed that DOD contained strong antimicrobial activities against broad range of microorganisms. In this study, we tried to modify DOD molecules by physical reaction to create new functionality or to enhance the antimicrobial activity of DOD. Aft er the harsh heat-treatment, a novel furan fatty acid (EODA) was produced from DOD. We confi rmed that EODA presented strong antibacterial activity against multidrug-resistant
Staphylococcus aureus and also EODA showed a recuperative eff ect of the beta-lactam antibiotics activity against methicillinresistant Staphylococcus aureus