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Rongshi Li

Rongshi Li

University of Nebraska Medical Center, USA

Title: Fragment-based and natural product-derived antibiotics against ESKAPE pathogens


Biography: Rongshi Li


Antibiotic drug resistance is a major threat to human health in the US and throughout the world. The Infectious Disease Society of America has classified “ESKAPE” (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) pathogens as those able to escape the biocidal action of antibiotics. Natural products, their derivatives, metabolites, and mimics account for more than half of the New Chemical Entities for anti-infective drugs. Marine natural products have contributed to eight drugs or cosmeceuticals that were approved by the US Food and Drug Administration and European Medicines Agency. Fragment-based and natural product-based derivatives are powerful for drug design and discovery. This talk will discuss the design, synthesis, and Structure-Activity- Relationships of natural product fragments and their derivatives for the development as potential antibiotics.