Antimicrobials, Multiple Drug Resistance & Antibiotics Resistance

Hydroxy fatty acids have been widely studied because they have various biological properties that can be utilized in many industries, compared with other types of fatty acids. Among the hydroxy fatty acids, our research group focused on 7,10-dihydroxy-8(E)-octadecenoic acid (DOD). We confi rmed that the strong antibacterial activities of DOD against foodborne pathogenic bacteria and plant pathogenic bacteria. Saccharide–fatty acid esters are important biodegradable emulsifiers in foods, cosmetics, and pharmaceuticals, hence, we focused on enzymatic synthesis of DOD-saccharide esters for industrial utilization of DOD. Several saccharides were screened as a substrate for esterifi cation with DOD. As a result, DOD xylitol ester was successfully produced at 50 with stirring at 200rpm for 24 hours in the presence of lipozyme RMIM as enzyme, and t-butyl alcohol as solvent. Its structure was confi rmed by GC/MS.