Antimicrobials, Multiple Drug Resistance & Antibiotics Resistance

Sepsis is a clinical syndrome caused by the body's immune and coagulation systems. Septic shock is a life-threatening condition that is characterized by low blood pressure despite adequate fl uid replacement, and organ dysfunction or failure. Sepsis is an important cause of death in people of all ages (Perner et al, 2017, Intensive Care Med). It is triggered by bacterial infections and by the release of LPS and LTA from bacterial surfaces (Ianaro et al, 2009 Mini Rev Med Chem; Kang et al, 2016 Arch Pharm Res).Here it will be described the construction of a new device for the selective removal of LPS and LTA from blood of patient with sepsis. Th is medical device is based on a resin conjugated with SET-M33 (Brunetti et al. 2016, Sci Reports), a synthetic peptide capable to strongly bind LPS and LTA from Gram-negative and Gram-positive bacteria, respectively. Th e device is able to remove selectively LPS and LTA from human blood samples without aff ecting serum protein content. It is currently under development for the clinical use in Intensive Care Units where sepsis is among the most imporant cause of death worldwide