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5th International Conference on Antibiotics & Antibiotic Resistance

Orlando, USA

Angel Josabad Alonso Castro

Angel Josabad Alonso Castro

University of Guanajuato, Mexico

Title: Antidiarrheal, vasorelaxant, and central nervous system effects of tilifodiolide, a diterpene from Salvia tiliifolia Vahl (Lamiaceae)


Biography: Angel Josabad Alonso Castro


Purpose: The purpose of this work was to evaluate the antidiarrheal, vasorelaxant, sedative, anxiolytic, and antidepressant actions of tilifodiolide (TFD), a natural diterpene obtained from Salvia tiliifolia Vahl (Lamiaceae).
Methods: The antidiarrheal activity of 1-50mg/kg TFD was assessed with the castor oil test, the charcoal meal test, and the castor oil induced-enteropooling. The relaxation effect of TFD (0.9-298µM) was carried out using smooth muscle tissues from rats, and its mechanism of action was evaluated using different inhibitors involved in muscle relaxation. The sedative, anxiolytic, and antidepressant effects of 1-100mg/kg TFD were calculated with the pentobarbital-induced sleeping time assay, the elevated plus maze test, the light-dark test, the cylinder exploratory test, and the forced swimming test.
Key findings: TFD exhibited anti-diarrheal activity (ED50=10.62mg/kg p.o.) and vasorelaxant effects (EC50=48±3.51µM). The coadministration of TFD with L-NAME or ODQ reverted the vasorelaxant action exposed by TFD alone. TFD exerted anxiolytic activity in all tests and decreased the time of immovability in the forced swimming test. 
Conclusions: TFD exerted antidiarrheal activity by decreasing the intestinal fluid accumulation, and vasorelaxant effects, mediated by NO and cGMP, in isolated aortic rings with intact-endothelium. TFD showed anxiolytic and antidepressant effects in mice.