Helieh S Oz
University of Kentucky, USA
Title: The surge of infectious and inflammatory complications and antibiotic resistance in humans
Biography
Biography: Helieh S Oz
Abstract
Alexander Fleming (1929) accidentally discovered antimicrobial effects of Penicillium mold which led to developments of modern medicine. Ever since antibiotics have become the cornerstone to fight pathogens and infectious diseases. Yet, with the advent of antibiotics resistance microbial, hospital-acquired infections, as well as emerge of the superbugs, have altered several clinical presentations and therapeutic approaches. As an example, sepsis and septic shock syndrome are the leading causes of death in critically ill patients and claiming over ¼ of million deaths annually in the United States alone. Microbial endotoxemia plays a key role in sepsis, released by colonic microorganisms. The incidence of sepsis in intensive care patients has been increasing. Recent years, the primary admission of elderly patients with cardiovascular disease (coronary artery disease and congestive heart failure) has been declining compared to escalating infectious diseases with explicitly labeled sepsis. Mycobacterium tuberculosis epidemic (TB) silently infects 1/3rd of the global population and is responsible for the death of almost 2 million people. In China, 1 million people develop the disease each year and about 100,000 become multi-drug resistance TB. This interactive presentation will aim to discuss antibiotics in health and in disease. In addition, possible preventive measures will be scrutinized.